Antimicrobial Activity of Ultrasonic Extracts of Two Chemotypes of Thymus serpyllum L. of Central Kazakhstan and their Polyphenolic Profiles

BACKGROUND: The medicinal plant of Thymus serpyllum L. in nature, depending on the geographical region, climatic conditions, and growing environment, is represented with some chemotypes. Composition quantitative content basic groups biologically active substances can be differed, thus their biological properties are also various.
 AIM: aim study was to determine possibility using ultrasonic extracts two chemotypes T. Central Kazakhstan as an antimicrobial agent against test strains microorganisms.
 MATERIALS AND METHODS: Two samples were extracted 70% ethanol ultrasound. polyphenol ultrasound determined LC-ultraviolet-ESI- tandem mass spectrometry technique. A activity performed eight Gram-positive bacteria, six Gram-negative four cultures fungi.
 RESULTS: similar composition phenolic compounds but differ a acids flavonoids, except for rosmarinic acid. have wide spectrum activity, exhibit bactericidal or bacteriostatic all tested bacteria fungi at concentration 0.0625–20 mg/ml, strength action CONCLUSION: considered potential drug activity. results chromatographic analysis will used standardization drug.